The Cell Motility Modulator Slit 2 is a Potent Inhibitor of Platelet Function Running title
نویسندگان
چکیده
Program in Cell Biology, The Hospital for Sick Children Rsrch Institute; Inst of Medical Science; Dept of Laboratory Medicine, Keenan Research Ctr, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and Toronto Platelet Immunobiology Group; Dept of Paediatrics, Div of Haematology/Oncology; Dept of Paediatrics, Div of Nephrology, The Hospital for Sick Children, Univ of Toronto; Canadian Blood Services, Toronto; Biotechnology Rsrch Institute, National Rsrch Council Canada, Montreal, Canada
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BACKGROUND Vascular injury and atherothrombosis involve vessel infiltration by inflammatory leukocytes, migration of medial vascular smooth muscle cells to the intimal layer, and ultimately acute thrombosis. A strategy to simultaneously target these pathological processes has yet to be identified. The secreted protein, Slit2, and its transmembrane receptor, Robo-1, repel neuronal migration in t...
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تاریخ انتشار 2012